Main Title |
Chemical Activation of Non-Mutagenic Nitrated Polycyclic Aromatic Hydrocarbons to Mutagens. |
Author |
Karpinsky, G. E. ;
McCoy, E. C. ;
Rosenkranz, H. S. ;
Mermelstein, R. ;
|
CORP Author |
Case Western Reserve Univ., Cleveland, OH. ;Xerox Corp., Rochester, NY.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1982 |
Report Number |
EPA/600/J-82/457; |
Stock Number |
PB86-185519 |
Additional Subjects |
Mutagens ;
Nitro compounds ;
Aromatic polycyclic hydrocarbons ;
Carcinogens ;
Reduction(Chemistry) ;
Bacteria ;
Enzymes ;
Hydroxylamine ;
Salmonella typhimurium ;
Reprints ;
Chemical activation
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-185519 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Nitrated polycyclic aromatic hydrocarbons, including carcinogens, may be non-mutagenic in microorganisms because bacterial nitroreductases are unable to reduce their nitro function to proximate mutagenic hydroxylamines. The reduction of the nitro moiety can be accomplished chemically in situ using zinc dust. The procedure, which is compatible with the Salmonella mutagenicity assay, was used to generate mutagens from chemicals which otherwise are non-mutagenic even in the presence of microsomal preparations. |