Record Display for the EPA National Library Catalog

RECORD NUMBER: 524 OF 2643

OLS Field Name OLS Field Data
Main Title Differences in Inflammatory Responses to Exposures of Concentrated Ambient Particles in Susceptible Volunteers.
Author M. A. Riedl ; W. S. Linn ; K. W. Clark ; D. Diaz-Sanchez
CORP Author California Univ., Los Angeles.; California State Air Resources Board, Sacramento.; California Environmental Protection Agency, Sacramento.
Year Published 2010
Report Number CARBRA-05-341
Stock Number PB2010-110811
Additional Subjects Particulates ; Air pollution ; Human health ; Environmental exposure ; Health effects ; Response ; Cardiopulmonary ; Biomarkers ; Respiratory system ; Tables(Data) ; Asthma ; Physiology ; Inflammation ; Monitoring ; Regulations ; Symptoms
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB2010-110811 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/21/2011
Collation 84p
Abstract
Respirable particulate matter (PM) is associated with harmful cardiopulmonary effects in humans. To test the hypothesis that individuals with certain susceptibility factors have heightened inflammatory and airway responses to PM exposure, a single-blind randomized dose crossover human study of controlled exposure to filtered air (FA), and concentrated ambient particles (CAPS) was conducted. We enrolled 10 mild- moderate asthmatic GSTMI null subjects, 10 mild- moderate asthmatic GSTMI present subjects and 10 healthy GSTMI present subjects to determine the short-term effects of CAPS exposure in individuals likely to be at risk for adverse effects. Outcome measures included symptom scores, physiologic measures (vital signs, spirometry, exhaled nitric oxide, heart rate variability) as well as serum, sputum, and nasal lavage samples for inflammatory biomarkers.