Record Display for the EPA National Library Catalog

RECORD NUMBER: 518 OF 2643

OLS Field Name OLS Field Data
Main Title Developmental Toxicity of Bromoxynil in Mice and Rats.
Author Rogers, J. M. ; Francis, B. M. ; Barbee, B. D. ; Chernoff, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Urbana-Champaign. Inst. for Environmental Studies.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/264;
Stock Number PB92-113265
Additional Subjects Toxicity ; Teratogenic compounds ; Herbicides ; Rats ; Mice ; Dose-response relationships ; Esters ; Body weight ; Organ weight ; Mortality ; Liver ; Spleen ; Thymus gland ; Adrenal glands ; Reprints ; Supernumerary ribs ; Bromoxynil
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB92-113265 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/24/1992
Collation 9p
Abstract
The developmental toxicity of the wide-spectrum herbicide bromoxynil (bromoxynil phenol; 3,5-dibromo-4-hydroxyphenyl cyanide) was evaluated in Sprague-Dawley rats and Swiss-Webster mice, and the developmental toxicity of its octanoate ester (2,6-dibromo-4-cyanophenyl octanoate) was evaluated in Sprague-Dawley rats. Animals were treated from Day 6 to Day 15 of gestation (presence of sperm or semen plug = 0 of gestation). The doses administered were as follows: bromoxynil phenol in the mouse, 342, 114, and 38 micromoles/kg/day; bromoxynil phenol and bromoxynil octanoate in the rat, 54, 18, and 6 micromoles/kg/day. Some animals were killed on selected days during treatment for measurement of organ weights sensitive to stress. In mice treated with bromoxynil phenol, maternal mortality was noted at 114 and 342 micromoles/kg/day, but surviving females gained weight normally. Liver to body weight ratios increased with increasing dose, but no consistent effect was seen on adrenal, thymus, or spleen weights. Fetuses of mice treated with the highest dose of bromoxynil phenol were of lower weight and had a higher incidence of supernumerary ribs than controls. In rats, bromoxynil phenol and its octanoate ester at the highest doses used caused no mortality but resulted in only transient decreases in maternal weight gain and significantly increased the liver to body weight ratio, but did not significantly alter adrenal, thymus, or spleen weight in the dams. (Copyright (c) 1991 by the Society of Toxicology.)