Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Developing relative potency factors for pesticide mixtures : biostatistical analyses of joint dose-response.
CORP Author Environmental Protection Agency, Cincinnati, OH. Office of Research and Development.
Publisher National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 2003
Report Number EPA/600/R-03/052
Stock Number PB2004-103101
OCLC Number 55150597
Subjects Pesticides--Toxicology. ; Pesticides--Dose-response relationship. ; Pesticides--Risk assessment. ; Toxicity testing. ; Environmental risk assessment.
Additional Subjects Pesticides ; Toxicology ; Mixtures ; Dosage ; Dose metrics ; Dose addition ; Dose measures ; Dose-response models ; Cumulative risks ; Combined exposures ; Algorithms ; Cumulative risk assessments ; Toxicologic action ; Biostatistical analyses ; Joint dose-response ; Relative potency factors ; Cumulative Risk Assessment(CRA)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB2004-103101 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 1 volume (various pagings) : illustrations ; 28 cm
Cumulative Risk Assessment (CRA) is defined in U.S. EPA's Risk Assessment Forum (RAF) CRA Framework (U.S. EPA, 2002a) as the combined risks from aggregate exposures to multiple agents or stressors. CRA has become an important research area, reflecting the interest of U.S. EPA's regional risk assessors, program offices, Office of Environmental Justice, and Office of Children's Risk. In implementing the requirements of the Food Quality Protection Act of 1996, U.S. EPA's Office of Pesticide Programs has developed guidance for conducting CRA's of chemicals that appear to act by a common mechanism of toxicity (U.S. EPA, 2002b). Because the organophosphorus pesticides (OPs) are considered to exert some of their toxic effects via a common toxicologic mechanism (i.e., cholinesterase inhibition), these compounds have been the subject of a CRA (U.S. EPA, 2001b). Additional CRA's may be performed on additional pesticide classes (e.g., triazinines, carbamates) and other co-occurring substances for which a common mode of action can be identified. The risk assessment method employed in the OP cumulative risk study is the Relative Potency Factor (RPF) approach (U.S. EPA, 2000). Dose addition is the critical methodological assumption, requiring the mixture components to act by the same toxic mode of action and to have similarly-shaped dose-response curves.
"September 2003." Shipping list no.: 2004-0288-M. Includes bibliographical references. "EPA/600/R-03/052." Microfiche.