Main Title |
Dimethyltin Dichloride: Investigations into Its Gastrointestinal Absorption and Transplacental Transfer. |
Author |
Noland, E. A. ;
McCauley, P. T. ;
Bull, R. J. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
Year Published |
1983 |
Report Number |
EPA-600/J-83-220; |
Stock Number |
PB84-213149 |
Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Absorption ;
Gastrointestinal system ;
Reprints ;
Dimethyltin dichloride ;
DMDC ;
Water pollution effects(Animals)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-213149 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Dimethyltin dichloride (DMDC) is commonly used as a stabilizer in PVC pipe used for transport of potable water. Learning deficiencies have been observed postnatally in pups from DMDC-treated dams. Studies were conducted with female Sprague-Dawley rats to determine whether DMDC was absorbed by the dam and transferred across the placenta to fetal blood and brain tissue. This was accomplished in three phases: (1) a comparison of absorption of organic and inorganic tin from drinking water, (2) a comparison of prenatal and postnatal levels of tin in the pups in cross-fostering studies, and (3) a (14C)dimethyltin dichloride tracer study to determine whether organic tin passed to the pup intact. Major findings include: (1) DMDC is absorbed in the gastrointestinal tract of the dam much more rapidly than Sn2+; (2) the more rapid absorption of DMDC results in higher concentration of tin in fetal blood and brain; and (3) in fetuses that receive tin as DMDC, both tin and the methyl carbon are absorbed by the dam and transferred to the blood and brain of the fetuses. |