Abstract |
Up to 48 hours after a single oral dose of 2 ml of rice bran oil containing 2,500 ppm of diphenyl chloride to white rats, approximately 10% of the diphenyl chloride administered was excreted in the feces, however absolutely none was observed in the urine. When rice bran oil containing 2,500 ppm of diphenyl chloride was administered to white rats once daily at a dosage of 2 ml each time for seven days continuously, it was noted that distribution of diphenyl chloride in the body showed the greatest accumulation in the skin, followed by the muscle, intestine, liver, pancreas and lungs. From the fact that there were differences in the diphenyl chloride compositional ratios in the ECD gas chromatograms of extracts from the tissue of white rats that had been administered diphenyl chloride, it is believed that the modality of accumulation within the body, metabolism and excretion of each of the components of the diphenyl chloride administered differs. |