||Critical Prenatal Periods for Chlorambucil-Induced Functional Alterations of the Rat Kidney.
Kavlock, R. J. ;
Rehnberg, B. F. ;
Rogers, E. H. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Congenital abnormalities ;
Prenatal exposure delayed effects ;
Neonatal diseases and abnormalities ;
Abnormalities(Drug induced) ;
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Previous studies have demonstrated that exposure of rats to chlorambucil during the period of metanephric differentiation results in morphological and functional alterations of the kidneys after birth. The present study describes the effects of chlorambucil treatment at various gestational ages on neonatal renal function. The results demonstrate that the critical period for the induction of specific renal defects and hypoplasia lies on day 11 of gestation, but functional alterations of the kidneys were observed after exposure on day 15 of gestation.