Main Title |
Effect of Ozone on Human Immunity: In vitro Responsiveness of Lymphocytes to Phytohemmagglutinin. |
Author |
Peterson, Mirzda L. ;
Rummo, Nicholas ;
House, Dennis ;
Harder., Shirley ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div. |
Year Published |
1976 |
Report Number |
EPA/600/J-78/025; |
Stock Number |
PB-284 764 |
Additional Subjects |
Ozone ;
Immunity ;
Toxicology ;
Humans ;
Lymphocytes ;
Blood cells ;
Exposure ;
In vitro analysis ;
Responses ;
Air pollution ;
Physiological effects ;
Reprints ;
Toxic substances ;
Plant agglutinins ;
Immunosuppression ;
Environmental health ;
Air pollution effects(Humans)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-284 764 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Peripheral blood lymphocytes from 20 human subjects exposed to 784 micrograms cu m ozone for 4 hours, and from 11 subjects exposed to clean air for the same length of time were studied for in vitro responsiveness to phytohemagglutinin (PHA). Thymus-derived (T) lymphocyte response to PHA (normal response is proliferation of lymphocytes) was significantly suppressed (P<.01) in samples obtained immediately after subjects' exposure to ozone. Recovery of response occurred 2 weeks postexposure. Responses were unchanged in subjects exposed to clean air. The significance of the suppression of T-cell response noted in this study is that (1) if continuous exposures to ozone are shown to induce an immunosuppressed state for a significant time period, an important factor in carcinogenesis might be elucidated; (2) immunosuppression may cause a progression of an already present tumor; (3) immunosuppression may enable endogenous latent infection such as tuberculosis to reactivate; and (4) immunosuppression may explain in part the relationship between chronic oxidant air pollution and influenza-like illnesses in population. |