Main Title |
Short-term screening test for quick responses to pollutants where health effects data are lacking {microform} / |
Author |
Drummond, John G. ;
Fenters, James D. ;
Ehrlich, Richard ;
Aranyi, Catherine ;
Schiff, Leonard J.
|
Other Authors |
|
CORP Author |
IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
Year Published |
1982 |
Report Number |
EPA/600/1-82/004; EPA-68-02-2088 |
Stock Number |
PB82-234303 |
Subjects |
Environmental health--United States ;
Pollution--United States--Physiological effect
|
Additional Subjects |
Screenings ;
Toxicology ;
Sulfates ;
Aerosols ;
Physiological effects ;
Air pollution ;
Exposure ;
Respiration ;
Sensitivity ;
Concentration(Composition) ;
Mice ;
Laboratory animals ;
Bacteria ;
Mortality ;
Bioassay ;
Air pollution effects(Animals) ;
Streptococcus pyogenes
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-234303 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
41 p. ; 28 cm. |
Abstract |
Results of assessment of various health effects parameters were correlated to determine which tests were the most sensitive indicators of toxic effects of exposure to sulfate aerosols. Inhalation studies were conducted involving single 3-hr exposure to various concentrations of cupric sulfate (0.43 - 2.64 mg/cu m), aluminum sulfate (1.65 - 2.75 mg/cu m), and aluminum ammonium sulfate (1.47 - 3.81 mg/cu m); and multiple 5 or 10 daily 3-hr exposures to cupric sulfate (0.1 mg/cu m). The test parameters studied in CD1 mice were changes in mortality after respiratory infection with Streptococcus pyogenes; pulmonary bactericidal activity; pulmonary cell number, type, viability, and ATP content; and pulmonary morphology by scanning electron microscopy. Trachael ciliary beating frequency and morphology were also studied in both CD1 mice and Syrian golden hamsters. |
Notes |
Caption title. "August 1982." "EPA-600/1-82-004." Microform. |