Main Title |
CASE-SAR (Computer Automated Structure Evaluation/Structure-Activity Relationship) Study of Mammalian Hepatic Azoreduction (Journal Version). |
Author |
Nesnow, S. ;
Bergman, H. ;
Bryant, B. J. ;
Helton, S. ;
Richard, A. ;
|
CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA-68-02-4456; EPA/600/J-88/189; |
Stock Number |
PB89-118806 |
Additional Subjects |
Azo dyes ;
Carcinogens ;
Toxicology ;
Oxidoreductases ;
Laboratory animals ;
Predictions ;
Computer programs ;
Reprints ;
Structure-activity relationship ;
Liver microsomes
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-118806 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
16p |
Abstract |
A group of 36 aryl azo dyes were examined for their ability to be reduced by rat liver microsomal azoreductase. This group of azo dyes featured a variety of substituents including sulfonic acid, phenol, nitro, amide, and methyl functionalities on phenyl, alpha-naphthyl, and beta-naphthyl rings. Reduction rate constants for each dye were obtained using a spectrophotometric method and anaerobic incubation conditions. The reduction rate constants and dye structures provided the data for a CASE-SAR fragment analysis and three major structure fragments associated with the ability of this group of azo dyes to be reduced were identified. These structural fragments may be useful in future predictions of the ability of azo dyes to undergo reduction by rat liver azoreductase. |