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RECORD NUMBER: 169 OF 287

OLS Field Name OLS Field Data
Main Title Letter from Phillips Petroleum Co. to US EPA Submitting Unpublished Studies on Cyclohexane with Attachments.
CORP Author Hazleton Labs., Inc., Falls Church, VA.; Phillips Petroleum Co., Odessa, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 40-8623065
Stock Number OTS0527456
Additional Subjects Toxicology ; Health effects ; Cyclohexane ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Primary Dermal Irritation ; Rabbits ; Dermal ; Primary Eye Irritation ; Oral ; Gavage ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Mice ; Chromosomal Effects ; Hamsters ; Toxic substances ; Laboratory animals ; CAS No 110-82-7
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NTIS  OTS0527456 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 86p
Abstract
Cyclohexane was tested for acute toxicity to rats (5/sex/group) exposed by inhalation to a nominal concentration of 32.88 mg/L. Exposure-related increased incidence of tremors, hyperactivity, rapid respiration, and prostration were noted in both sexes. Similar exposure of male mice (4/group) led to slight reduction in respiratory rate in 1 animal and increased rate in the other 3. No evidence of upper airway irritancy was seen. Washed and unwashed primary eye irritation studies were conducted in rabbits (6/group) exposed to cyclohexane. Conjunctival redness was noted at one hour, but cleared by 24 hours. A primary skin irritation test in rabbits (6/sex) showed no evidence of irritation; whether skin sites were abraded or intact was not reported. An acute oral toxicity study in rats (5/sex/group) exposed to a single dose of 5000 mg/kg cyclohexane showed only transitory clinical signs of depression, salivation, and soft feces. Rabbits (6/sex) dermally exposed to single applications of 2000 mg/kg cyclohexane showed no evidence of systemic toxicity, but slight transient erythema and edema were noted. Salmonella/microsome plate assays in Salmonella typhimurium tester strains TA98, TA100, TA1535, TA1537, and TA1538 showed no evidence of mutagenicity with exposure to 7 graded doses of 7.1 to 5200 ug/plate. A mouse lymphoma forward mutation assay conducted at test concentrations up to 100 ug/ml in the presence of S9 gave negative results. An in vitro sister chromatid exchange test was conducted in Chinese hamster ovary cells exposed to concentrations up to 25 ug/ml; negative results were seen.