Main Title |
Dermal absorption of 14C-labeled 4,4'-methylenedianiline (4,4'-MDA) in rats, guinea pigs, and monkeys : final report / |
Author |
El-Hawari, M. ;
Stoltz, M. ;
Czarnecki, D. ;
Alm, P.
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Other Authors |
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CORP Author |
Midwest Research Inst., Kansas City, MO.;Environmental Protection Agency, Washington, DC. Office of Pesticide Programs. |
Publisher |
U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, Field Studies Branch, |
Year Published |
1986 |
Report Number |
68-02-3938; EPA 560/5-86-011; EPA-68-02-3938; MRI-8501-A(21) |
Stock Number |
PB86-179819 |
OCLC Number |
42843573 |
Subjects |
Skin absorption ;
4,4p1s-methylenedianiline ;
4,41-methylenedianiline
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Additional Subjects |
Absorption(Biology) ;
Skin(Anatomy) ;
Rats ;
Guinea pigs ;
Monkeys ;
Laboratory animals ;
Measurement ;
Therapy ;
Dosage ;
Methylenedianiline ;
Dermal absorption
|
Internet Access |
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Local Library Info |
Library |
Local Subject |
Local Note |
N/A |
CAS No. 101-77-9 ; (4,4'-MDA); diaminodiphenylmethane; MDA |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 560-5-86-011 |
|
Headquarters Library/Washington,DC |
05/04/2015 |
ELBD ARCHIVE |
EPA 560-5-86-011 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
NTIS |
PB86-179819 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
1 volume (various pagings) : tables ; 28 cm |
Abstract |
To help determine workplace exposure to 4,4'-MDA, studies were performed in male rats, guinea pigs and monkeys treated topically with a low (2 mg/kg) or high (20 mg/kg) dose of 14C-4,4'-MDA. Conditions of treatment (dosage, dose regimens, and occlusion) were assessed. The disposition of 4,4'-MDA was also examined after i.v. dosing. In rats, 43 and 10% of the low dose was recovered in urine and feces during a 96 h period; 2% remained in tissues and skin washing removed 25% of dose. The remainder (26%) was recovered by skin extraction and solubilization. The percent of dose absorbed decreased by increasing the dose, but the total amount absorbed (approx. 0.25 mg/rat) was similar after both doses. In g. pigs, 10 and 18% of the low dose was excreted in urine and feces; 1% was recovered in tissue, 41% in the skin wash and 29% from the application area. The percent of dose absorbed decreased following the high dose, but the amounts absorbed (in mg/animal) doubled. |
Notes |
"January 15, 1986." "EPA Prime Contract no. 68-02-3938." "MRI Project No. 8501-A(21)." |