Record Display for the EPA National Library Catalog
RECORD NUMBER: 1 OF 2Main Title | Comparative Toxicity of Azinphos-Methyl to House Mice, Laboratory Mice, Deer Mice, and Gray-Tailed Voles. | |||||||||||
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Author | Meyers, S. M. ; Wolff, J. O. ; | |||||||||||
CORP Author | ManTech Environmental Technology, Inc., Corvallis, OR. ;Oregon State Univ., Corvallis. Dept. of Fisheries and Wildlife.;Corvallis Environmental Research Lab., OR. | |||||||||||
Publisher | c1994 | |||||||||||
Year Published | 1994 | |||||||||||
Report Number | EPA-68-C8-0006; EPA/600/J-94/272; | |||||||||||
Stock Number | PB94-182367 | |||||||||||
Additional Subjects | Toxicity ; Pesticides ; Insecticides ; Risk assessment ; Mice ; Dosage ; Mortality ; Body weight ; Field tests ; Oral administration ; Acute exposure ; Lethal doses ; Cholinesterase ; Reprints ; Azinphos-methyl ; Guthion ; Mus musculus ; Microtus canicaudus ; Peromyscus maniculatus ; Voles | |||||||||||
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Collation | 7p | |||||||||||
Abstract | The authors conducted a laboratory toxicity study on house mice and laboratory mice, gray-tailed voles, and deer mice as part of a comprehensive laboratory and field study to field-validate laboratory-based risk assessment of argichemicals. The single dose oral LD50 for the organophosphorus insecticide azinphos-methyl was 10, 11, 32, 48 mg/kg body mass in wild house mice, laboratory mice, gray-tailed voles, and deer mice, respectively. The authors conclude that (1) laboratory mice were not representative of deer mice or gray-tailed voles with respect to sensitivity to the pesticide, but provided a conservative estimates for risk assessment; (2) 5-d dietary LC50 tests provide substantially higher estimates of toxicity to rodents than do 10-d test; and (3) ChE depression of 45 to 50% was lethal. |