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RECORD NUMBER: 4 OF 5

OLS Field Name OLS Field Data
Main Title Strain Comparisons of DFP Neurotoxicity in Rats.
Author Gordon, C. J. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/354;
Stock Number PB93-228609
Additional Subjects Isoflurophate ; Toxicity ; Nervous system ; Cholinesterase inhibitors ; Species diversity ; Rats ; Cholinesterase ; Body temperature ; Motor activity ; Pesticides ; Dose-response relationships ; Graphs(Charts) ; Reprints ;
Holdings
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Status
NTIS  PB93-228609 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 15p
Abstract
The purpose of the study was to assess intraspecies differences in behavioral and autonomic function in three strains of rat following administration of diisopropyl fluorophosphate (DFP), an irreversible inhibitor of acetylcholinesterase activity. Male rats of the Long-Evans (LE), Fischer 344 (F344), and Sprague-Dawley (SD) strains were administered DFP at doses of 0 to 1.5 mg/kg (s.c.). The animals were placed 60 min later into one of two motor activity chambers and tested for 30 min. Motor activity was measured using either a Doppler-based system or a commercial photocell device. Following measurement of motor activity in the Doppler system, body temperature was measured and blood was then withdrawn by cardiac puncture and analyzed for serum cholinesterase activity. The remaining rats were retested 24 hr after DFP administration in the photocell device. The results showed a significant influence of strain on the effects of DFP. Motor activity of LE rats was reduced by DFP at doses of 1.0 and 1.5 mg/kg, whereas the activity of F344 rats was reduced only at 1.5 mg/kg.