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Main Title Mutagenic Screening of Marker Grenade Dyes by the 'Salmonella' Reversion Assay, L5178Y/TK(+)/(-)Mouse Lymphoma Assay, and In vivo Sister Chromatid Exchange Analysis in Mice (Journal Version).
Author Moore, M. M. ; Allen, J. W. ; Claxton, L. ; Doerr, C. ; Gwaltney, C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM. Inhalation Toxicology Research Inst.;Army Medical Research and Development Command, Washington, DC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/238;
Stock Number PB89-142756
Additional Subjects Dyes ; Dye markers ; Grenades ; Toxicity ; Chromosome abnormalities ; Bioassay ; Mutagens ; Mice ; Lymphomas ; Thymidines ; Phosphotransferases ; Salmonella ; In vivo ; Chemical marking agents ; Anthraquinones ; Indanthrenes ; Cultures(Biology) ; Reprints ; Colony-forming units assay ; Occupational safety and health ; Sister chromatid exchanges
Holdings
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Status
NTIS  PB89-142756 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 10p
Abstract
Two dyes (C.I. Solvent Yellow No. 33, and a C.I. Solvent Yellow No. 33-C.I. Solvent Green No. 3 mixture) were tested for mutagenicity and for sister chromatid exchange (SCE) in vivo in mice. Purified yellow dye was tested with and without exogenous activation in the Salmonella reversion assay and the mouse lymphoma assay. Neither C.I. Solvent Yellow No. 33 nor the C.I. Solvent Yellow No. 33-C.I. Solvent Green No. 3 mixture was positive for inducing in vivo SCE. All three dyes were tested in the standard plate incorporation test in seven strains. The dyes were negative with and without exogenous activation in strains TA98, TA1535, and TA1538. One test with TA1537 was positive using the yellow dye. All three dyes gave weakly positive results with S-9 in TA100 and were clearly positive in TA102 and TA104 both with and without S-9. They induced mutation at the thymidine kinase locus in mouse lymphoma cells, produced both large- and small-colony trifluorothymidine-resistant mutants, and were clastogenic. The purified yellow dye was capable of inducing a slight positive SCE response in mouse lymphoma cells only in the presence of S-9.