Main Title |
Reproductive Effects Assessment Group's Report on the Mutagenicity of Inorganic Arsenic. |
Author |
Jacobson-Kram, D. ;
Montalbano, D. ;
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Gallaudet Coll., Washington, DC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/349; |
Stock Number |
PB86-175445 |
Additional Subjects |
Reproduction(Biology) ;
Toxicology ;
Arsenic inorganic compounds ;
Metalloids ;
Bioassay ;
In vitro analysis ;
Chromosomes ;
In vivo analysis ;
Deoxyribonucleic acid ;
Reprints ;
Mutagenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-175445 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
Various inorganic compounds of arsenic have been tested for mutagenicity in a variety of test systems ranging in complexity from bacteria to peripheral lymphocytes of exposed human beings. Although a great deal of the data are contradictory, the weight of evidence supports the following conclusions: (1) Arsenic is either inactive or extremely weak for the induction of gene mutations in vitro; (2) Arsenic is clastogenic and induces sister chromatid exchanges (SCE) in a variety of cell types, including human cells, in vitro; trivalent arsenic is approximately an order of magnitude more potent than pentavalent arsenic. (3) Arsenic does not appear to induce chromosome aberrations in vivo in experimental animals; (4) Several studies suggest that human beings exposed to arsenic demonstrate higher frequencies of SCE and chromosomal aberrations in peripheral lymphocytes; the quality of these studies is generally poor. |