Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Binding of Chemical Carcinogens and Mutagens to Rat Hemoglobin.
Author Pereira, M. A. ; Chang, Lina W. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1980
Report Number EPA-600/J-81-148;
Stock Number PB81-212144
Additional Subjects Carcinogens ; Mutagens ; Binding ; Hemoglobins ; Rats ; Blood proteins ; Reprints ; NTISEPAORD
Library Call Number Additional Info Location Last
NTIS  PB81-212144 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
The alkylation of hemoglobin is a proposed dose monitor for chemical carcinogens and mutagens. The binding of fifteen chemical carcinogens and mutagens to rat hemoglobin was determined. Direct acting carcinogens and indirect acting carcinogens including aromatic amines, halogenated hydrocarbons, nitrosamines, polycyclic aromatic hydrocarbons, aflatoxin B1 and benzene bound hemoglobin. The efficiency of carcinogen and mutagen hemoglobin was dose dependent and ranged from 0.007 to 2.3% of an oral dose. The binding of chemical carcinogens and mutagens to hemoglobin would appear to be generic so that it could be developed into a dose monitor for a large number of known carcinogens and mutagens.