Record Display for the EPA National Library Catalog

RECORD NUMBER: 11 OF 48

OLS Field Name OLS Field Data
Main Title Effect of Methyl Oleate Hydroperoxide, a Possible Toxic Ozone Intermediate, on Human Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Erythrocytes.
Author Williams, P. ; Calabrese, E. J. ; Moore, G. S. ;
CORP Author Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-805797; EPA/600/J-83/276;
Stock Number PB85-173177
Additional Subjects Ozone ; Oxidation ; Toxicology ; Blood cells ; Erythrocytes ; Humans ; Sensitivity ; Reprints ; Dehydrogenase/glucose-phosphate ; Oleic acid/hydroperoxyl-methyl ; Glutathiones
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB85-173177 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
Erythrocytes of both normal and glucose 6-phosphate dehydrogenase (G-6-PD)-deficient humans responded in a dose-dependent manner to the oxidant stress of methyl oleate hydroperoxide (MOHP) as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels, and decreases in reduced glutathione (GSH). The G-6-PD-deficient erythrocytes displayed a markedly enhanced sensitivity to MOHP-induced decreases in G-6-PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels.