Main Title |
Evaluation of the Dorset Sheep as a Predictive Animal Model for the Response of Glucose-6-Phosphate Dehydrogenase-Deficient Human Erythocytes to a Proposed Systemic Toxic Ozone Intermediate, Methyl Oleate Ozonide. |
Author |
Calabrese, E. J. ;
Williams, P. S. ;
Moore, G. S. ;
|
CORP Author |
Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-R-805797; EPA/600/J-83/274; |
Stock Number |
PB85-173193 |
Additional Subjects |
Ozone ;
Hemoglobins ;
Toxicology ;
Erythrocytes ;
Blood cells ;
Humans ;
Sheep ;
Reprints ;
Dehydrogenase/glucose-phosphate ;
Oleic acid/methyl-ozonyl ;
Animal models ;
Glutathiones
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-173193 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Erythrocytes of both glucose-6-phosphate dehydrogenase (G-6-PD)-deficient humans and Dorest sheep, an animal model with an erythrocyte G-6-PD deficiency, responded in a dose-dependent manner to the oxidant stress of methyl oleate ozonide (MOO) as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels, and decreases in GSH. However, the human G-6-PD-deficient erythrocytes were considerably more sensitive to the formation of METHB than the sheep erythrocytes while the reverse was the case for the GSH parameter. The results suggest a qualitative difference in the response of sheep erythrocytes and human G-6-PD-deficient erythrocytes to MOO that seriously questions the value of the sheep erythrocyte as a quantitatively accurate predictive model. (Copyright (c) 1983 by Academic Press, Inc.) |