Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title In vitro microbiological mutagenecity and unscheduled DNA synthesis studies of eighteen pesticides /
Author Simmon, Vincent F.
CORP Author SRI International, Menlo Park, CA.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1979
Report Number EPA 600/1-79/041; EPA-68-01-2458
Stock Number PB80-133226
OCLC Number 37391220
Subjects Mutagenesis. ; Pesticides--Toxicology.
Additional Subjects Deoxyribonucleic acids ; Pesticides ; Mutagens ; Bacteria ; In vitro analysis ; Escherichia coli ; Microbiology ; Synthesis ; Risk ; Salmonella typhimurium ; Enterobacteriaceae ; Bioassay ; Mutagenesis ; Saccharomyces cerevisiae
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJAD  EPA 600/1-79-041 Region 3 Library/Philadelphia, PA 01/14/2000
EJBD ARCHIVE EPA 600-1-79-041 Headquarters Library/Washington,DC 01/30/2012
EJBD  EPA 600-1-79-041 Headquarters Library/Washington,DC 04/23/2014
EKAM  EPA 600/1-79/041 Region 4 Library/Atlanta,GA 08/01/1997
EKBD  EPA-600/1-79-041 Research Triangle Park Library/RTP, NC 06/30/2000
EKCD  EPA-600/1-79-041 NHEERL/GED Library/Gulf Breeze,FL 05/29/2018
ELDD  EPA-600/1-79-041 NHEERL/MED Library/Duluth,MN 09/08/2000
NTIS  PB80-133226 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation x, 165 pages : tables ; 28 cm.
Eighteen pesticides being reviewed as a part of the EPA Substitute Chemical Program were tested for mutagenic activity by the following in vitro procedures: (1) Reverse mutation in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100 and in Escherichia coli WP2 uvrA. (2) Induction of mitotic recombination in the yeast Saccharomyces cerevisiae D3. (3) Relative toxicity assays in DNA repair-proficient and -deficient strains of E. coli (strains W3110 and p3478, respectively) and of Bacillus subtilis (strains H17 and M45 respectively). (4) Unscheduled DNA synthesis (UDS) in human fibroblasts (WI-38 cells). Nine of the 18 pesticides were mutagenic in one or more of the assays. One compound, demeton, was mutagenic in all of them. Trichlorofon was mutagenic in all the assays except those for relative toxicity. Acephat was mutagenic in the Salmonella typhimurium in TA100, Saccharomyces cerevisiae D3, and UDS assays. Dicamba, 2,4-D acid, 2,4-DB acid, and propanil were positive only in the assay for relative toxicity. Disulfoton was positive only in the UDS assay, and then only in the absence of the metabolic activation system. Crotoxyphos was positive only in the S. cerevisiae D3 assay.
"EPA-600/1-79-041." "Contract No. 68-01-2458." Includes bibliographical references (pages 163-164).