Main Title |
Dose Response of 'Cryptosporidium parvum' in Outbred Neonatal CD-1 Mice. |
Author |
Finch, G. R. ;
Daniels, C. W. ;
Black, E. K. ;
Schaefer, F. W. ;
Belosevic, M. ;
|
CORP Author |
Environmental Protection Agency, Cincinnati, OH. Risk Reduction Engineering Lab. ;Alberta Univ., Edmonton. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-94/089; |
Stock Number |
PB94-146289 |
Additional Subjects |
Dose-response relationships ;
Biological models ;
Cryptosporidium parvum ;
Parasitic diseases ;
Dosage ;
Mice ;
Oocysts ;
Biological effects ;
Oral administration ;
Water supply ;
Disinfectants ;
Public health ;
Drinking water ;
Water treatment ;
Reprints ;
Infective dose
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-146289 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies. (Copyright (c) 1993 American Society for Microbiology.) |