Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title NTP Technical Report on Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice.
CORP Author National Toxicology Program, Research Triangle Park, NC.
Publisher Jul 93
Year Published 1993
Report Number NIH/PUB-93-3385 ;NIH/TOX-36;
Stock Number PB94-121035
Additional Subjects Toxicity ; Pesticides ; Fertilizers ; Behavior ; Oral administration ; Rats ; Mice ; Mixtures ; Body weight ; Drinking behavior ; Ground water ; Organ weight ; Tables(Data) ; Chemical water pollutants ; Pathology ; Reproduction(Biology) ; Mutagens ;
Library Call Number Additional Info Location Last
NTIS  PB94-121035 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/27/1994
Collation 157p
Toxicity studies were performed with pesticide and fertilizer mixtures representative of groundwater contamination found in California and Iowa. The California mixtures was composed of aldicarb, atrazine, 1,2-dibromo-3-chloropropane, 1,2-dichloropropane, ethylene dibromode, simazine, and ammonium nitrate. The Iowa mixture contained alachlor, atrazine, cyanazine, metolachlor, metribuzin, and ammonium nitrate. The mixtures were administered in drinking water (with 512 ppm propylene glycol) to F344/N rats and B6C3F1 mice of each sex at concentrations ranging from 0.1X to 100X, where 1X represented the median concentrations of the individual chemicals found in studies of groundwater contamination from normal agricultural activities. This report focuses primarily on 26-week toxicity studies describing histopathology, clinical pathology, neurobehavior/neuropathology, and reproductive system effects. The genetic toxicity of the mixtures was assessed by determining the frequency of micronuclei in peripheral blood of mice and evaluating micronuclei and sister chromatid exchanges in splenocytes from female mice and male rats.