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RECORD NUMBER: 197 OF 1146

OLS Field Name OLS Field Data
Main Title Comparative Toxicity to Rats of Methoxyacetone and Five Other Aliphatic Ketones in their Drinking Water with Cover Letter.
CORP Author Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 23 Mar 1977
Year Published 1977
Report Number 878212140;
Stock Number OTS-0206068
Additional Subjects Toxicity ; Neurotoxicity ; Ketones ; Alaphatic ketones ; Drinking water ; Laboratory animals ; Rats ; Dosage ; Concentrations ; Comparisons ; Methoxyacetone ; Methyl isobutyl ketone ; CAS No. 108-10-1
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NTIS  OTS-0206068 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/29/2008
Collation 58p
Abstract
The toxicity of methoxyacetone was compared to that of methyl n-butyl ketone and a series of four other aliphatic ketones (diethyl ketone, ethyl n- buty1 ketone, methyl isobutyl ketone-, methyl tert-butyl ketone) with particular reference to neurotoxicity. Preliminary studies were performed to establish toxic dosage levels of the ketones, which were administered in drinking water for seven days at concentrations of 0.5% and 1% (estimated to be equivalent to approx. 0.3 to 0.9 gm/kg/day). Reduced food and water intake and low body weight gains probably reflected rejection of the water because of taste. The concentrations used were at or near maximum water solubility of most of the ketones, methoxyacetone being the most notable exception. Methoxyacetone produced no toxic effects at these concentrations or at 2%, but 6% and 20% solutions of this material for 7 days produced dosage-related effects similar to those of the other ketones.