Record Display for the EPA National Library Catalog
RECORD NUMBER: 132 OF 339
|OLS Field Name||OLS Field Data|
|Main Title||Evaluation of Chemicals Used for Drinking Water Disinfection for Production of Chromosomal Damage and Sperm-Head Abnormalities in Mice.|
|Author||Meier, J. R. ; Bull, R. J. ; Stober, J. A. ; Cimino, M. C. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. ;Litton Bionetics, Inc., Kensington, MD.|
|Additional Subjects||In vivo analysis ; Water treatment ; Disinfectants ; Oxidizers ; Toxicology ; Bioassay ; Chromosome abnormalities ; Public health ; Laboratory animals ; Carcinogens ; Mutagens ; Toxicity ; Potable water ; Genetics ; Reprints ; Chemical treatment ; Water pollution effects(Animals) ; Water pollution effects(Humans)|
Chemical oxidants are commonly added during water treatment for disinfection purposes. These chemicals have not been tested previously for their ability to induce genetic damage in vivo. Chlorine (hypochlorite and hypochlorous acid), monochloramine, chlorine dioxide, sodium chlorite and sodium chlorate were evaluated for induction of chromosomal aberrations and micronuclei in bone marrow of CD-1 mice, and for induction of spermhead abnormalities in B6C3F1 mice. There was no evidence of other effects with any of the disinfectants. Halogenated acetonitriles, which have previously been shown to form in the stomach following oral dosing of sodium hypochlorite to rats, were also tested in the spermhead abnormality assay but gave no indication of an effect.