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RECORD NUMBER: 132 OF 339

OLS Field Name OLS Field Data
Main Title Evaluation of Chemicals Used for Drinking Water Disinfection for Production of Chromosomal Damage and Sperm-Head Abnormalities in Mice.
Author Meier, J. R. ; Bull, R. J. ; Stober, J. A. ; Cimino, M. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Litton Bionetics, Inc., Kensington, MD.
Year Published 1985
Report Number EPA/600/J-85/046;
Stock Number PB85-210128
Additional Subjects In vivo analysis ; Water treatment ; Disinfectants ; Oxidizers ; Toxicology ; Bioassay ; Chromosome abnormalities ; Public health ; Laboratory animals ; Carcinogens ; Mutagens ; Toxicity ; Potable water ; Genetics ; Reprints ; Chemical treatment ; Water pollution effects(Animals) ; Water pollution effects(Humans)
Holdings
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Status
NTIS  PB85-210128 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 12p
Abstract
Chemical oxidants are commonly added during water treatment for disinfection purposes. These chemicals have not been tested previously for their ability to induce genetic damage in vivo. Chlorine (hypochlorite and hypochlorous acid), monochloramine, chlorine dioxide, sodium chlorite and sodium chlorate were evaluated for induction of chromosomal aberrations and micronuclei in bone marrow of CD-1 mice, and for induction of spermhead abnormalities in B6C3F1 mice. There was no evidence of other effects with any of the disinfectants. Halogenated acetonitriles, which have previously been shown to form in the stomach following oral dosing of sodium hypochlorite to rats, were also tested in the spermhead abnormality assay but gave no indication of an effect.