Main Title |
Reduction of Microsomial Phospholipids in Experimental Cardiac Discompensation. (Heart-Lung of Rat Preparation). |
Author |
Panagia, V. ;
Minelli, R. ;
Zonta., F. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section. |
Year Published |
1971 |
Report Number |
EPA-TR-67-73 ;APTIC-48029; |
Stock Number |
PB-237 730-T |
Additional Subjects |
Cardiovascular diseases ;
Lipids ;
Ribosomes ;
Biochemistry ;
Heart ;
Pathophysiology ;
Etiology ;
Mitochondria ;
In vitro analysis ;
Italy ;
Translations ;
Experimental data ;
Molecular biology
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-237 730-T |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Because previous results had shown that experimental heart failure was not caused by reduction of oxidable substrate and high-energy phosphate content in myocardial tissue, further experiments have been performed in order to see if any alteration in subcellular membranes, which are strictly involved in the excitation-contraction coupling mechanism, could be detected in failing heart. Experimental cardiac failure was realized by imposing a high load on the left ventricle of the rat heart-lung preparation. The determination of mitochondrial and microsomal phospholipid classes has shown: (1) no change in mitochondrial phospholipids and (2) a 20% reduction in phosphatidylcholine, 35% in phosphatidylserine and 34% in sphingomyelin in the microsomal fraction from failed heart. |