||Toxicological review of chlorine dioxide and chlorite (CAS No. 10049-04-4 and 7758-19-2) : in support of summary information on the Integrated Risk Information System (IRIS) /
Patel, Yogendra. ;
||Environmental Protection Agency, Washington, DC. Office of Water.
|| U.S. Environmental Protection Agency, National Center for Environmental Assessment,
Hazardous substances--Health aspects--Reporting.
Chlorine dioxide ;
Environmental exposure ;
Health hazards ;
Risk assessment ;
Dose-response relationships ;
Hazardous substances ;
Chemical properties ;
Physical properties ;
Dermal absorption ;
Carcinogenicity tests ;
Oral dosage ;
Chronic disease ;
Chronic exposure ;
Factor analysis ;
IRIS(Integrated Risk Information System)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||64 pages ; 28 cm
This document presents background and justification for the hazard and dose-response assessment summaries in the U.S. Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS). IRIS summaries may include an oral reference dose (RfD), inhalation reference concentration (RfC), and a carcinogenicity assessment. The RfD and RfC provide quantitative information for noncancer dose-response assessments. The RfD is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis but may not exist for other toxic effects such as some carcinogenic responses. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious noncancer effects during a lifetime. The inhalation RfC is analogous to the oral RfD, but it provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for the respiratory system (portal of entry) and for effects peripheral to the respiratory system (extra respiratory or systemic effects). It is generally expressed in units of mg/m3.
"September 2000." "EPA/635/R-00/007." Includes bibliographical references. "PB2001-100633." Microfiche.