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RECORD NUMBER: 145 OF 398

OLS Field Name OLS Field Data
Main Title Evaluation of Triethanolamine 99 in the Rat Hepatocyte Unscheduled Dna Synthesis Assay (Sanitized).
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-890001201S
Stock Number OTS0520713
Additional Subjects Toxicology ; Health effects ; Triethanolamine (102-71-6) ; Genotoxicity ; Dna Effects ; Mammals ; Rats ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 102-71-6
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NTIS  OTS0520713 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 16p
Abstract
Genotoxicity of triethanolamine was evaluated in the rat hepatocyte primary culture/DNA repair assay. The compound was tested at concentrations of 1x10E-8, 1x10E-7, 1x10E-6, 1x10E-5, 1x10E-4, 1x10E-3, 1x10E-2, and 1x10E-1 M in Williams Medium E. The negative control group was cell cultures exposed to the medium only. The positive control groups were cell cultures exposed to the medium plus 2-acetylaminofluorene or 9,10-dimethyl-1,2-benzanthracene (1x10E-6, 1x10E-5, and 1x10E-4 M), in 1% DMSO. The treatment was cytotoxic to cell cultures at 1x10E-1 M. The treatment had no effect on the rate of DNA repair, indicating a lack of genotoxicity of triethanolamine in this cell culture assay.