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RECORD NUMBER: 20 OF 30

OLS Field Name OLS Field Data
Main Title Induction of Prophage Lambda by Chlorinated Organics: Detection of Some Single-Species/Single-Site Carcinogens.
Author DeMarini, D. M. ; Brooks, H. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/231;
Stock Number PB92-195841
Additional Subjects Carcinogens ; Phage lambda ; DNA damage ; Escherichia coli ; Salmonella ; Mutagenicity tests ; DNA repair ; SOS response(Genetics) ; Plaque assay ; Carcinogenicity tests ; Tables(Data) ; Dose-response relationships ; Reprints ; Organochlorine compounds
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB92-195841 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/22/1992
Collation 16p
Abstract
Twenty-eight chlorinated organic compounds were evaluated for their ability to induce DNA damage using the Microscreen prophage-induction assay in Escherichia coli. Comparison of the performance characteristics of the prophage-induction and Salmonella assays to rodent carcinogenicity assays showed that the prophage-induction assay had a somewhat higher specificity than did the Salmonella assay (70% vs. 50%); sensitivity, concordance, and positive and negative predictivity were similar for the two microbial assays. The Microscreen prophage-induction assay failed to detect eight carcinogens, perhaps due to toxicity or other unknown factors; five of these eight carcinogens were detected by the Salmonella assay. However, the prophage-induction assay did detect six carcinogens that were not detected by the Salmonella assay, and five of these were single-species, single-site carcinogens, mostly mouse liver carcinogens. (Copyright (c) 1992 Wiley-Liss, Inc.)