Record Display for the EPA National Library Catalog
RECORD NUMBER: 209 OF 602Main Title | Evaluation of selected pesticides as chemical mutagens 'in vitro' and 'in vivo' studies / | |||||||||||||||||||||||||||||||||||||
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Author | Simmon, Vincent F. | |||||||||||||||||||||||||||||||||||||
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CORP Author | Stanford Research Institute, Menlo Park, Calif.;Health Effects Research Lab., Research Triangle Park, N.C. | |||||||||||||||||||||||||||||||||||||
Publisher | N.T.I.S., | |||||||||||||||||||||||||||||||||||||
Year Published | 1977 | |||||||||||||||||||||||||||||||||||||
Report Number | EPA/600/1-77/028; SRI-LSU-3493; EPA-68-01-2458 | |||||||||||||||||||||||||||||||||||||
Stock Number | PB 268 647 | |||||||||||||||||||||||||||||||||||||
OCLC Number | 07038421 | |||||||||||||||||||||||||||||||||||||
Subjects | Chemical mutagenesis ; Pesticides--Testing ; Mutagenicity testing ; Mutagens ; Mutagens--Testing | |||||||||||||||||||||||||||||||||||||
Additional Subjects | Pesticides ; Mutagens ; Toxicology ; In vivo analysis ; In vitro analysis ; Toxicity ; Genetics ; Mutations ; Deoxyribonucleic acids ; Biosynthesis ; Bioassay ; Mice ; Laboratory animals ; Tissue culture ; Microorganisms ; Dosage ; Mutagenesis | |||||||||||||||||||||||||||||||||||||
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Collation | ix, 238 pages : illustrations ; 28 cm | |||||||||||||||||||||||||||||||||||||
Abstract | Twenty pesticides were studied for mutagenic activity by several in vitro and in vivo test procedures. The pesticides reviewed were: monocrotophos, bromacil, cacodylic acid, captan, chlorpyrifos, dinoseb, DSMA, fenthion, folpet, azinphos-methyl, malathion, methomyl, monuron, MSMA, parathion, parathion-methyl, quintozene (PCNB), phorate, simazine, and trifluralin. Ten of the twenty compounds were evaluated in vivo by the mouse dominant lethal test. All twenty compounds were tested in vitro. None of the ten compounds tested in the mouse produced a dominant lethal response. Ten of the twenty compounds were mutagenic in one or more in vitro assays. Two were mutagenic in all of the in vitro assays: captan and folpet. |
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Notes | Prepared for the Health Effects Research Lab, Research Triangle Park, N.C., by Stanford Research Institute, Menlo Park, Ca. Contract number 68-01-2458. EPA-600/1-77-028. |