||Induction and Reduction of Sister Chromatid Exchange by CCNU in Human Lymphocytes in Vitro.
McKenzie, W. H. ;
Lambert, B. ;
||North Carolina State Univ. at Raleigh.;Health Effects Research Lab., Research Triangle Park, NC.
Cesium 137 ;
In vitro analysis ;
Sister chromatid exchange
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The chromosome aberration yield for human lymphocytes exposed in vitro to various doses of 137 Cesium has been studied. Dicentric, total acentric and excess acentric data were seen to follow a Possion distribution. Calculated total hits demonstrated over-dispersion which could possibly be accounted for by a greater occurrence of single-hit phenomena being repaired than two-hit exchange processes. The resulting distribution generally contained an under-representation of cells with odd numbers of hits and an over-representation of zero- and even-hit classes as compared with Poisson predicted values.