Pesticides found in homes may result from indoor applications to control household pests or by translocation from outdoor sources. Pesticides disperse according to their physical properties and other factors such as human activity, residential air exchange, temperature and humidity. A study was conducted in the U.S. EPA Indoor Air Quality test house to determine the spatial and temporal distribution of chlorpyrifos following a professional crack and crevice application in the kitchen. Following the application, measurements were made in the kitchen, den and master bedroom over 21 days. Airborne concentrations were collected using both polyurethane foam (PUF) and a XAD/PUF media. Transferable chlorpyrifos residues were determined using a press sampler and C18 extraction discs. Spatial distributions, application surface loadings, and redeposition were measured using 10 residues. Surface wipes were and vacuum dislodgeable residues were collected in the kitchen and carpeted den, respectively. Measured airborne concentrations were similar for both samplers, detected in all rooms sampled, reached maximal concentrations 24 hours post-application and steadily declined by day 21. Concentrations measured from deposition coupons suggest that airborne residues sorbed to deposition coupons in all room sampled. However, carpet sections, due to high background concentrations of chlorpyrifos, poorly resolve the contribution of the application to carpet residues.