Abstract |
By expanding the number of species tested in assessing the toxicology of a chemical one is able to gain considerable insight into its mechanism of action, biodegradability, organ specific toxicity, and acute and potential chronic effects. The expansion of comparative toxicology from reliance on laboratory mammals to the inclusion of feral mammals, fish, birds, and some invertebrates is highly desirable in order to better understand the range of responses to a chemical in its interactions with the various target systems possible in different animals. With the inclusion of additional species in toxicity testing has come the need for the development of protocols to standardize approaches for the use of such new species. |