Abstract |
Aromatic amines and compounds related through metabolism are used widely in industry. As a result of such applications, they are also dispersed into the environment, thereby creating a potential for human exposure. Four aromatic are known to lead to urinary tract cancer in exposed humans, and some are also responsible for the induction of methemoglobinemia. Some other structurally similar amines are carcinogenic to one or more tissues in laboratory animals. This report summarizes the key information concerning the occurrence, analysis, and toxicology of the aromatic amines and then considers six specific amines in detail. The following substances were studied: Aniline, 4,4'Methylene-Bis (2Chloraniline), 2,4-Diaminotoluene, trifluralin, p-Cresidine, and furazolidone. The following topics are covered: occurrence in the environment, general analysis, metabolism, carcinogenc potency and risk estimation, and epidemiology. |