Record Display for the EPA National Library Catalog

RECORD NUMBER: 311 OF 1030

OLS Field Name OLS Field Data
Main Title Evaluation of WHO-IPCS Chemicals by the C3H10T1/2CL8 Morphological Transformation Bioassay.
Author Nesnow, S. ; Curtis, G. ; Garland, H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-600/D-84-070;
Stock Number PB84-167501
Additional Subjects Bioassays ; Chemical compounds ; Cell morphology ; Environmental surveys ; Malignant neoplasms ; Lactams ; Toluidine ; Benzenes ; Cultures(Biology) ; Public health ; Concentration(Composition) ; Nitrogen organic compounds ; Toxic substances ; Phosphoramide/hexamethyl ; Benzene ; Benzene/allyl-(methylenedi-oxy) ; Cancer
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-167501 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 24p
Abstract
In the laboratory, the authors have utilized C3H10T1/2 cells to study the effects of environmental chemicals on mammalian cells. During the course of these studies, they bioassayed a wide variety of chemicals including polycyclic aromatic hydrocarbons, alkylating agents, aromatic amines, azodyes, solvents, pesticides, mycotoxins, carbamates, and nitroaromatics. The results of these studies are summarized. In the present study, the authors evaluated the effects of hexamethylphosphoramide (HMPA). o-toluidine, benzene, safrole, and caprolactam on oncogenic transformation of C3H10T1/2 cells. The original protocol of Reznikoff et al. (1973a) was used with minor variation.