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RECORD NUMBER: 302 OF 1030

OLS Field Name OLS Field Data
Main Title Evaluation of In Vitro Production of the Beta Chemokine, MCP-1, as a Diagnostic Test in diisocyante Asthma, with Cover Letter dated 03/03/1999.
CORP Author International Isocyanate Inst., Parsippany, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1999
Stock Number OTS0573880
Additional Subjects Toxicology ; Health effects ; Benzene ; 1 ; 3-Diisocyanatomethyl ; Biochemistry ; Mammals ; Humans ; In vitro ; Industrial hygiene ; CAS No 26471-62-5
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NTIS  OTS0573880 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/09/2010
Collation 14p
Abstract
The primary aim of this proposal is to validate dlisocyanate (DIISO) specific in vitro cellular MCP-1 as a diagnostic marker of occupational asthma (OA) by using the specific bronchoprovocation test (SBPT) as the gold standard for diagnosis. A secondary aim of the study is to evaluate the sensitivity and specificity ofin vitro serum DIISO-HSA specific IgG and IgE responses for identification ofdiisocyanate asthma (DA) confirmed by the SBPT. This report summarizes and discusses the results obtained in this study.