Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 9

OLS Field Name OLS Field Data
Main Title Teratology and acute toxicology of selected chemical pesticides administered by inhalation /
Author Newell, Gordon W.
Other Authors
Author Title of a Work
Dilley, James V.
Publisher U.S. Environmental Protection Agency Health Effects Research Laboratory,
Year Published 1978
Report Number EPA 600/1-78-003; PB 277 077; EPA-68-02-1751
Stock Number PB-277 077
OCLC Number 20440544
Subjects Pesticides--Toxicology. ; Teratogenic agents
Additional Subjects Toxicology ; Congenital abnormalities ; Pesticides ; Insecticides ; Aerosol generators ; Aerosols ; Concentration(Composition) ; Test chambers ; Exposure ; Rats ; Bioassay ; Laboratory animals ; Females ; Males ; Lethal dosage ; Pregnancy ; Embryology ; Ingestion(Biology) ; Cholinesterase ; Toxicity ; Pathology ; Experimental data ; Teratology ; Inhalation ; Fetuses ; Parathion ; Intravenous injections ; Topical administration ; Azinphosmethyl ; Phorate
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91013F9I.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-78-003 Region 3 Library/Philadelphia, PA 11/14/1992
EJBD ARCHIVE EPA 600-1-78-003 Headquarters Library/Washington,DC 06/04/2012
EJBD  EPA 600-1-78-003 Headquarters Library/Washington,DC 05/16/2014
EJED  EPA-600/1-78-003 OCSPP Chemical Library/Washington,DC 02/23/1990
EKAM  RA1242.P43N545 Region 4 Library/Atlanta,GA 09/29/1995
EKBD  EPA-600/1-78-003 Research Triangle Park Library/RTP, NC 06/13/2003
ELDM  RA1242.P43N545 NHEERL/MED Library/Duluth,MN 05/21/1999
NTIS  PB-277 077 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation xii, 49 p. : tables ; 28 cm.
Abstract
A method was developed for generating pesticide aerosols within the respirable particle size range of 0.3 to 3.0 micrometers. Analytical methods were established for determining pesticide concentrations in chamber air samples and in tissues. A unique chamber exposure system was developed that permitted the simultaneous exposure of four different groups of rats to four different concentrations of pesticide from a single generation source. Parathion, methyl parathion, Thimet, Guthion, and Azodrin were administered to rats by the oral, dermal, intravenous or inhalation routes, and the LD50s or LC50s were compared. Inhalation was the most toxic route of administration, followed by the intravenous, oral, and then dermal routes. Females were more sensitive than males to parathion and Thimet by all routes of administration. Azodrin was more toxic to females by the intravenous and oral routes, and Guthion was more toxic to females by dermal application. No correlation was found between mortality and cholinesterase inhibition or blood or liver pesticide content. No gross or histopathological lesions were identified that could be attributed to pesticide treatment. Timed-pregnant rats were exposed to vapors/aerosols of chloroform, ethylene thiourea, Thimet, Bromacil, and Simazine for 1 to 3 hours daily on days 7 through 14 of gestation. No dose-related terata were found in any of the studies.
Notes
"EPA 600/1-78-003." "PB 277 077." "Contract no. 68-02-1751." "January 1978."