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OLS Field Name OLS Field Data
Main Title Changes in Testicular and Serum Hormone Concentratios in the Male Rat Following Treatment with 'm'-Dinitrobenzene (Journal Version).
Author Rehnberg, G. L. ; Linder, R. E. ; Goldman, J. M. ; Hein, J. F. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/203;
Stock Number PB89-144455
Additional Subjects Toxicity ; Hormones ; Testes ; Blood serum ; Gonadotropins ; Hypothalamus ; Nitroaryl compounds ; Pituitary gland ; Atrophy ; Rats ; Testosterone ; Reproductive system ; Reprints ; Dinitrobenzenes ; Biological effects ; Epithelium
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB89-144455 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 12p
Abstract
m-Dinitrobenzene (m-DNB)-induced testicular atrophy has been attributed to a direct effect upon the germinal epithelium. However, such degenerative changes in the germinal epithelium should induce shifts in the testicular hormonal milieu, which would in turn alter the hypothalmic-pituitary gonadal axis in general. The study evaluated the endocrine status of male rats following a single oral dose of m-DNB (32 mg m-DNB/kg). Serum and pituitary leuteinizing hormone, follicle-stimulating hormone (FSH), and protactin and hypothalamic gonadotropin-releasing hormone (GnRH) concentrations were determined. Testosterone and androgen-binding protein concentrations in serum, interstitial fluid, seminiferous tubule fluid, and caput epididymis were also determined. In vitro basal and hCG-stimulated testosterone release was determined in the decapsulated testis. These data demonstrate that m-DNB exerts a direct effect on the testes and not through alterations in hypothalamic and pituitary control of gonadal function. (Copyright (c) 1988 Academic Press, Inc.)