Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 19

Main Title Health assessment document for inorganic arsenic /
Other Authors
Author Title of a Work
Sivulka, Donna J.,
Publisher United States Environmental Protection Agency, Environmental Criteria and Assessment Office,
Year Published 1985
Report Number EPA/600-S8-83-021F
OCLC Number 15456671
Subjects Arsenic--Toxicology ; Arsenic--Carcinogenicity ; Arsenic in the body ; Arsenic Poisoning ; Carcinogens
Internet Access
Description Access URL
Connect to the resource https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=2000TK1F.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJBD  EPA 600-S8-83-021F Headquarters Library/Washington,DC 05/29/2018
EJBD  EPA 600-S8-83-021f Headquarters Library/Washington,DC 06/05/2018
ELBD ARCHIVE EPA 600-S8-83-021F In Binder Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
Collation 5 pages ; 28 cm
Notes
Caption title. Distributed to depository libraries in microfiche. "Aug. 1985." "EPA/600-S8-83-021F."
Contents Notes
Inorganic arsenic, predominantly the tri- and pentavalent forms, is emitted to the environment primarily through smelting activity, biocide use and glass manufacturing. Monitoring data indicate a concentration of equal to or less than 0.1 microgram/cu m for most locations. Major routes of absorption of inorganic arsenic in the general population are inhalation and ingestion. Inhaled inorganic arsenic deposited in the lungs is eventually absorbed. Most ingested soluble inorganic arsenic is absorbed, whereas insoluble forms pass through the gastrointestinal tract with negligible absorption. Inorganic arsenic metabolism in man is complicated by biotransformation processes which include the methylation and oxidation-reduction interconversion of inorganic arsenic. Long-term accumulation of inorganic arsenic does not generally occur in physiologically active compartments in the body; renal clearance appears to be the major route of excretion of absorbed inorganic arsenic. Acute symptoms of inorganic arsenic poisoning include severe gastrointestinal damage, facial edema, cardiovascular reactions, peripheral nervous system disturbances, and hematopoietic system effects. General population concerns arising from long-term exposures to moderate levels of inorganic arsenic include respiratory tract cancer, skin cancer, non-cancerous skin lesions, peripheral neuropathological effects and cardiovascular effects. There appears to be a nutritional requirement for low levels of inorganic arsenic in certain experimental animals; however, this requirement has not yet been established in man.