There are, under development, a number of new biological technologies that target the cleanup of contaminated hazardous waste sites. These technologies utilize specific organisms to degrade organic chemical contaminants to less toxic species. The attraction to the new area of treatment in the United States is the restrictions on waste burial, costs of conventional alternative technology, and the assumption that biological processes are more environmentally beging. Two areas of development that will be discussed in the paper are the use of white rot fungus wood degrader for water and soil treatment and a pentachlorophenol degrader. The white rot based treatment is focused on the treatment of wood treating wastes, ie. creasote, pentachlorophenol and associated materials.