||Dominant Lethal Effects of Subchronic Acrylamide Administration in the Male Long-Evans Rat.
Smith, M. K. ;
Zenick, H. ;
Preston, R. J. ;
George, E. L. ;
Long, R. E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Cincinnati Univ., OH. Dept. of Environmental Health. ;Oak Ridge National Lab., TN.
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Acrylamide, a widely used vinyl monomer, is well known as a neurotoxin but inactive as a mutagen in bacterial test systems. The experiments reported demonstrate that after subchronic oral dosing in the male rat, acrylamide induced significant elevations in both pre and post implantation loss following dominant lethal testing. These effects were seen at doses which failed to produce clinical or pathological evidence of neurotoxicity.