Record Display for the EPA National Library Catalog
RECORD NUMBER: 844 OF 977Main Title | Studies on the Percutaneous Absorption of Parathion and Paraoxon. V. Rate of Absorption of Paraoxon. | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Author | Fredriksson., Torsten ; | |||||||||||
CORP Author | Communicable Disease Center, Atlanta, Ga. | |||||||||||
Year Published | 1961 | |||||||||||
Stock Number | PB-280 010 | |||||||||||
Additional Subjects | Pesticides ; Insecticides ; Toxicology ; Enzymes ; Cholinesterase inhibitors ; Dosage ; Responses ; Parenteral infusions ; Absorption(Biology) ; Skin(Anatomy) ; Cats ; Bioassay ; Laboratory animals ; Reprints ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester) | |||||||||||
Holdings |
|
|||||||||||
Collation | 4p | |||||||||||
Abstract | The rate of percutaneous absorption of paraoxon (E 600, or diethyl 4-nitrophenyl phosphate) has been determined by dose-response comparison following this mode of administration and intravenous infusion in the cat. The rate of inhibition of plasma cholinesterase activity was chosen as the parameter. Under the conditions of the study, the rate of percutaneous absorption was found to be constant in a given skin. By extrapolation from the activity curves, it was possible to determine the time required for paraoxon to diffuse from the topical deposit to the blood stream. This latency period was found to be approximately 12 minutes. |