Record Display for the EPA National Library Catalog
RECORD NUMBER: 13 OF 1585Main Title | 5,7-Dihydroxytryptamine Injections Increase Glial Fibrillary Acidic Protein in the Hypothalamus of Adult Rats. | |||||||||||
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Author | Frankfurt, M. ; O'Callaghan, J. ; Beaudet, A. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Rockefeller Univ., New York. Lab. of Neuroendocrinology. ;Montreal Neurological Inst. (Quebec). Neuroanatomy Lab. | |||||||||||
Publisher | c1991 | |||||||||||
Year Published | 1991 | |||||||||||
Report Number | EPA/600/J-91/020; | |||||||||||
Stock Number | PB92-143924 | |||||||||||
Additional Subjects | Glial fibrillary acidic protein ; Hypothalamus ; 5-7-dihydroxytryptamine ; Rats ; Astrocytes ; Serotonin ; Radioimmunoassay ; Immunohistochemistry ; Reprints ; | |||||||||||
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Collation | 5p | |||||||||||
Abstract | The distribution and level of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxic, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. Measurement of GFAP levels demonstrated a significant increase on the ipsilateral side of 5,7-DHT-treated rats as compared to sham-treated rats. |