Main Title |
Multiple-Endpoint Mutagenesis with Chinese Hamster Ovary (CHO) Cells: Evaluation with Eight Carcinogenic and Non-Carcinogenic Compounds. |
Author |
Hsie, A. W. ;
San Sebastian, J. R. ;
Perdue, S. W. ;
Schenley, R. L. ;
Winters, M. D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Texas Univ. Medical Branch at Galveston. Dept. of Preventive Medicine and Community Health. ;Oak Ridge National Lab., TN. ;Pharmakon Research International, Inc., Waverly, PA. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/295; |
Stock Number |
PB88-185137 |
Additional Subjects |
Mutagens ;
Ovary ;
Hamsters ;
Chromosomes ;
Carcinogens ;
Malignant neoplasms ;
Reprints ;
Cytotoxins ;
Hypoxanthine phosphoribosyltransferase ;
Sister chromatid exchange ;
Carcinoma
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-185137 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
21p |
Abstract |
Using Chinese hamster ovary (CHO) cells in culture, the authors have defined an assay, CHO/HGPRT, to quantify mutagen-induced cytotoxicity and mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus. This assay permits elucidation of the structure-activity relationship and analysis of relative mutagenic potency of various classes of chemical mutagens. By expanding the CHO/HGPRT assay to include chromosome aberration and sister-chromatid exchange (SCE), the authors can analyze the interrelationships of these four distinct biological effects and compare each endpoint for its predictive power of human-level effect. (Copyright (c) 1987 by Hemisphere Publishing Corporation.) |