Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Rationale for Assessment of Risk from Exposure to 2,3,7,8-TCDD.
Author Mukerjee, D. ; Stara, J. F. ; Schaum., J. L. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/524;
Stock Number PB90-232133
Additional Subjects Toxicology ; Epidemiology ; Public health ; Bioassay ; Reproduction(Biology) ; Carcinogens ; Liver neoplasms ; Reprints ; Risk assessment ; Tetrachlorodibenzodioxin ; Carcinogenicity tests ; Occupational safety and health ; Health hazards ; Environmental exposure pathways
Library Call Number Additional Info Location Last
NTIS  PB90-232133 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 10p
The human health risk assessment is supported by methodology for utilizing toxic effects in animals consisting of carcinogenic and noncarcinogenic responses as a result of chronic, subchronic and acute exposures. One of the initial steps in a risk assessment activity involves the estimation of exposure levels. These estimates are typically based on either direct environmental measurements or predictions obtained from fate and transport models. The decision to develop assessment of risk from chronic exposure based on a nonthreshold model is made if a chemical demonstrates carcinogenic activity in animal bioassays and/or in human epidemiological studies. In the absence of any positive human epidemiologic data, it is assumed that a substance which induces a statistically significant carcinogenic response in animals has the probability to cause cancer in humans. The carcinogenic potential of 2,3,7,8-TCDD has been established based on chronic exposure in rodents. In addition, 2,3,7,8-TCDD has also been shown to be a liver cancer promoter in rodents. In the risk assessment on dioxins based on chronic exposure in experimental animals, 2,3,7,8-TCDD is regarded as a carcinogenic substance.