Record Display for the EPA National Library Catalog
RECORD NUMBER: 8 OF 8Main Title | Validation of chemical and biological techniques for evaluation of vapors in ambient air/mutagenicity testing of twelve (12) vapor-phase compounds / | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Author | Hughes, T. ; Sparacino, C. ; Frazier, S. | |||||||||||
Other Authors |
|
|||||||||||
CORP Author | Research Triangle Inst., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Publisher | U.S. Environmental Protection Agency, Health Effects Research Laboratory, | |||||||||||
Year Published | 1984 | |||||||||||
Report Number | EPA/600/1-84/005; EPA-68-02-3170 | |||||||||||
Stock Number | PB84-164219 | |||||||||||
Subjects | Air--Analysis ; Mutagenicity testing | |||||||||||
Additional Subjects | Mutagens ; Air pollution ; Chemical analysis ; Bioassay ; Laboratory animals ; Sampling ; Chloromethanes ; Formaldehyde ; Epichlorohydrin ; Toxicity ; Ethylene oxide ; Nitrobenzenes ; Hydrogen sulfide ; Butenes ; Propylene ; Acetylene ; Ames bioassay ; Toxic substances ; Tenax resins ; Methane/chloro ; Ethylene/trichloro ; Aroclors ; Ethane/dichloro ; Propane/nitro | |||||||||||
Holdings |
|
|||||||||||
Collation | 204 pages ; 28 cm | |||||||||||
Abstract | The overall objective of this research was to further validate Ames mutagenicity preincubation system for detection of vapors in ambient air. Parametes for detection of vapors in the Ames/Salmonella mutagenicity assay were investigated and 12 vapor-phase compounds were tested for mutagenic potential in the above validated protocol with strains TA97, TA98 and TA100, both with and without Aroclor-induced hamster and rat liver S9. The 12 vapor-phase compounds tested were: methylene chloride, formaldehyde, trichloroethylene, ethylene dichloride, epichlorohydrin, nitropropane, nitrobenzene, hydrogen sulfide, butene, propylene, acetylene, and ethylene oxide. Ethylene oxide, epichlorohydrin, ethylene dichloride and methylene chloride were mutagenic. |
|||||||||||
Notes | Caption title. "March 1984." "EPA-600/1-84-005." Microfiche. |