Main Title |
DNA Alterations (Chapter 3). |
Author |
Shugart, L. ;
Bickham, J. ;
Jackim, G. ;
McMahon, G. ;
Ridley, W. ;
|
CORP Author |
Environmental Research Lab., Narragansett, RI. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/A-93/164 ;ERLN-1087; |
Stock Number |
PB93-221828 |
Additional Subjects |
Biological markers ;
Organisms ;
Exposure ;
Toxicity ;
Chemical compounds ;
Deoxyribonucleic acids ;
Mutations ;
DNA damage ;
Diseases ;
Cells(Biology) ;
Monitoring ;
Chromosomes ;
DNA repair ;
Abnormalities ;
Bioassay ;
Reprints ;
Oncogenes activation
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-221828 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
33p |
Abstract |
The exposure of an organism to genotoxic chemicals may induce a cascade of genetic events. Initially, structural alterations to DNA are formed. Next, the DNA damage is processed and subsequently expressed in mutant gene products. Finally, diseases result from the genetic damage. The detection and quantitation of various events in the sequence may be employed as biomarkers of exposure and effects in organisms exposed to genotoxic agents in the environment. The methods to monitor exposure to genotoxic chemicals are based upon either: (1) direct measurement of DNA structural change; (2) the detection of their consequences by measuring DNA repair directly or indirectly; or (3) the production of mutations in the genome of the exposed organisms. Adducts are a type of structural change involving covalent attachments of a chemical or its metabolite to DNA. Several analytical procedures are currently used to monitor the formation of DNA adducts directly. (Copyright (c) 1992 by Lewis Publishers.) |