Main Title |
Diethyldithiocarbamate Increases Distribution of Cadmium to Brain but Prevents Cadmium-Induced Neurotoxicity. |
Author |
O'Callaghan, J. P. ;
Miller, D. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/097; |
Stock Number |
PB86-217460 |
Additional Subjects |
Cadmium ;
Brain ;
Toxicology ;
Distribution ;
Therapy ;
Reprints ;
Dithiocarbamates ;
Neurotoxicity ;
Heavy metals
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-217460 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Dithiocarbamates exhibit potent metal-binding properties which have been exploited in a variety of applications, one of which is chelation therapy for heavy metal toxicity. Such therapy, however, promotes the accumulation of metals in the brain, a side effect which may result in neurotoxicity. To examine this possibility the authors used morphological and biochemical indices to assess the effects of diethyldithiocarbamate (DDC) on cadmium-induced neurotoxicity in the newborn rat. Co-administration of DDC prevented the neurotoxic effects of cadmium while causing a persistent increase in the distribution of cadmium to brain. |