Main Title |
Carcinogenicity of Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Dichloroacetic Acid, in Mouse Liver. |
Author |
Herren-Freund, S. L. ;
Pereira, M. A. ;
Khoury, M. D. ;
Olson, G. ;
|
CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Pathology Associates, Inc., Cincinnati, OH.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1987 |
Report Number |
EPA-68-03-3215; EPA/600/J-87/275; |
Stock Number |
PB88-185541 |
Additional Subjects |
Acetic acid ;
Liver neoplasms ;
Mice ;
Adenoma ;
Carcinogens ;
Phenobarbital ;
Drugs ;
Toxicity ;
Toxicology ;
Potable water ;
Contaminants ;
Water pollution ;
Reprints ;
Trichloroacetic acid ;
Trichloroethylene ;
Dichloroacetate ;
Drug synergism ;
Ethylnitrosourea
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-185541 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when given by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic acid (DCA) as a minor metabolite. These chlorinated acetic acids have not been shown to be genotoxic; although, they have been shown to induce peroxisome proliferation. Therefore, the authors determined the ability of TCE, TCA, or DCA to act as tumor promoters in mouse liver. Therefore our results demonstrate that DCA and TCA are hepatocarcinogens in B6C3F1 mice although there has been no previous evidence of their geonotoxicity. (Copyright (c) 1987 by Academic Press, Inc.) |