Includes bibliographical references and indexes.

"Biostatistical Methods focuses on the assessment of risks and relative risks on the basis of clinical investigations. It develops basic concepts and derives biostatistical methods through both the application of classical mathematical statistical tools and more modern likelihood-based theories." "The first half of the book presents methods for the analysis of single and multiple 2 x 2 tables for cross-sectional, prospective, and retrospective (case-control) sampling, with and without matching using fixed and two-stage random effects models. The text then moves on to present a more modern likelihood- or model-based approach, which includes unconditional and conditional logistic regression; the analysis of count data and the Poisson regression model; and the analysis of event time data, including the proportional hazards and multiplicative intensity models. The book contains a technical appendix that presents the core mathematical statistical theory used for the development of classical and modern statistical methods."--Jacket.