||Toxicity of Hexamethylphosphoramide in Rats.
Kimbrough, Renate ;
Gaines., Thomas B. ;
||Communicable Disease Center, Atlanta, Ga.
Pest control ;
Laboratory animals ;
Reproductive system ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The data show that HMPA has a very specific effect on the testes of rats when fed at a dietary level of 750 p.p.m. which may be compared with a level of 2.500 p.p.m. in food necessary to cause 100 per cent sterility in male flies. This comparison shows that the safety of any future use of HMPA must be based on its moderate toxicity to mammals and on limitation of their contact with it rather than on any important difference in the inherent susceptibility of mammals and insects to the compound.